Sierra Williams, Ph.D.

Assistant Professor of Chemistry


Keck Science

Areas of Expertise



B.S. in Chemistry, Temple University; Ph.D. in Chemistry, University of California, Irvine

Research and Publications

Williams, S. J.; Hwang, C. S.; Prescher, J. A. Orthogonal Bioluminescent Probes with Disubstituted Luciferins. Biochemistry, 2021, 60, 563–572.

Hutchinson, M. A.; Deeyaa, B. D.; Byrne, S. R.; Williams, S. J.; Rokita, S. E. Directing Quinone Methide-Dependent Alkylation and Cross-Linking of Nucleic Acids with Quaternary Amines. Bioconjugate Chem. 2020, 31, 1486–1496.

Williams, S. J.; Prescher, J. A. Building Biological Flashlights: Orthogonal Luciferases and Luciferins for In Vivo Imaging. Acc. Chem. Res. 2019, 52, 3039–3050.

Streifel, B. C.; Lundin, J. G.; Sanders, A. M.; Gold, K. A.; Wilems, T. S.; Williams, S. J.; Cosgriff-Hernandez, E.; Wynne, J. H. Hemostatic and Absorbent PolyHIPE-Kaolin Composites for 3D Printable Wound Dressing Materials. Macromol. Biosci. 2018, 18, e1700414.

Streifel, B. C.; Parker, J. F.; Giles, S. L.; Williams, S. J.; Duncan, J. H.; Wynne, J. Porosity Control in High Internal Phase Emulsion Templated Polyelectrolytes via Ionic Crosslinking. J. Polym. Sci. Part A: Polym. Chem. 2016, 54, 2486–2492.

Steele, A. D.; Keohane, C. E.; Knouse, K. W.; Rossiter, S. E.; Williams, S. J.; Wuest, W. M. Diverted Total Synthesis of Promysalin Analogs Demonstrates that an Iron-Binding Motif is Responsible for its Narrow-Spectrum Antibacterial Activity. J. Am. Chem. Soc. 2016, 138, 5833–5836.